nano-I-drops is a research project on ocular drug delivery at the University Eye Hospital Tübingen (Germany) aiming to transfer nanoparticles made of natural building blocks from research stage to clinical application.
Our DNA nanoparticles show excellent adherence to the ocular surface leading to increased drug uptake and improved efficacy. This allows for a much lower drug concentration and less frequent application and thereby reduced side effects.
Our nanoparticles consist of lipid-modified DNA-strands that self-assemble into micelles with a hydrophobic core and a hydrophilic corona. Various substances can be loaded via three different strategies:
I) hydrophobic loading into the core
II) covalent binding to the complementary DNA-strand
III) aptameric loading
You can find more detailed information on our platform technology here:
nano-I-drops technology can be combined with a wide variety of ophthalmic drugs, including the ones that have been abandoned due to severe side effects or lack of formulation.
We are currently addressing several segments of the ophthalmic market. First results on therapy options for glaucoma and anti-infectives are very promising.
If you are interested in joint development, collaboration or you just want to learn more about our research, please contact us.
University Eye Hospital Tübingen
+49 7071 29 87888
further information: University Eye Hospital Tübingen