Solving ocular drug delivery challenges by applying DNA technology

nano-I-drops is a research project on ocular drug delivery at the University Eye Hospital Tübingen (Germany) aiming to transfer nanoparticles made of natural building blocks from research stage to clinical application.

 

Our DNA nanoparticles show excellent adherence to the ocular surface leading to increased drug uptake and improved efficacy. This allows for a much lower drug concentration and less frequent application and thereby reduced side effects.

 

 


Technology

Our nanoparticles consist of lipid-modified DNA-strands that self-assemble into micelles with a hydrophobic core and a hydrophilic corona. Various substances can be loaded via three different strategies:

 

I)   hydrophobic loading into the core

II)  covalent binding to the complementary DNA-strand

III) aptameric loading


You can find more detailed information on our platform technology here:

Patent: Means and methods for ocular drug delivery

Paper: DNA nanoparticles for ophthalmic drug delivery

Collaboration opportunities

nano-I-drops technology can be combined with a wide variety of ophthalmic drugs, including the ones that have been abandoned due to severe side effects or lack of formulation.

 

 

 

We are currently addressing several segments of the ophthalmic market. First results on therapy options for glaucoma and anti-infectives are very promising.

 

 

If you are interested in joint development, collaboration or you just want to learn more about our research, please contact us.

 

Prizes & funding

Poster Prize DOG 2014
Poster Prize DOG 2014
Winner Poster Prize DOG 2013
Poster Prize DOG 2013
Winner of the Dutch Venture Challenge 2012
Venture Challenge 2012
Winner Science4Life Concept Phase 2015
Science4Life Concept Phase 2015
2. Place Science2Start 2014
Science2Start 2014
Winner EYEnovative Research Prize 2013
EYEnovative Research Prize 2013

Contact info

nano-I-drops

University Eye Hospital Tübingen

Elfriede-Aulhorn-Str. 7

D-72076 Tübingen

 

sven.schnichels[at]med.uni-tuebingen.de

+49 7071 29 87888

 

 

further information: University Eye Hospital Tübingen

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